صحت تشخیصی مقاطع بافتی منجمد (Frozen section) در تومورهای دستگاه ژنیتال زنان

The use of Frozen-section during surgical procedures, gives the surgeon valuable information and guides him to perform the appropriate surgical procedure. In order to determine the accuracy of Frozen-section in gynecologic surgery, we compared the results of 172 gynecologic Frozen-section diagnosis with their final diagnosis in Mirza Kockak Khan Hospital, from 1378 to 1379. A total of 106 ovarian, 43 uterine, 10 lymph node and 13 other tissue samples were obtained. The Frozen-section diagnosis was compatible with the final diagnosis in 93.6 percent of cases. The sensitivity for non benign lesions was 82.5 percent and the specificity was 96.8 percent. The positive and negative predictive values were 84 percents and 98 percent respectively. 2.3 percent of cases were falsely positive, 1.7 percent falsely negative and 1.2 percent over estimated the degree of malignancy. There was no underestimation and 1.2 percent were uncertain. Frozen-section was found to identify correctly 8 of 8 metastatic ovarian tumors and 1 of 2 germ cell tumors. The accuracy of Frozen-section was 25 percent in ovarian borderline tumors, 60 percent in ovarian mucinous and 80 percent in serous tumors. With the exception of borderline and mucinous ovarian tumors, Frozen-section diagnosis is sufficiently accurate for clinical use. Performing multiple sections is recommended in the Frozen-section diagnosis of mucinous ovarian tumors.